Identification of HLA-B44 subtypes associated with extended MHC haplotypes |
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| Authors: | Margot S. Kruskall MD Elizabeth E. Eynon Zuheir Awdeh Chester A. Alper Edmond J. Yunis |
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| Affiliation: | (1) The Center for Blood Research, Departments of Pediatrics, Pathology, and Medicine, Children's Hospital Medical Center, Beth Israel Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA;(2) American Red Cross Blood Services - Northeast Region, Dedham, Massachusetts, USA;(3) Blood Bank, Beth Israel Hospital, 330 Brookline Avenue, 02215 Boston, MA, USA |
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| Abstract: | The HLA class I antigen B44 is found in each of two different extended major histocompatibility haplotypes (allele combinations of HLA-B, HLA-DR, and complement genes BF, C2, C4A, and C4B in linkage disequilibrium). Using isoelectric focusing, two variants of HLA-B44 were identified. The basic variant was found in all cell lines with the extended haplotype HLA-B44, DR7, FC31, and the acidic variant in all cell lines with the extended haplotype HLA-B44, DR4, SC30. The occurrence of each antigen variant with a unique extended haplotype explains previous observations concerning the nonrandom association of B44 variants with DR antigens. |
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