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Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines |
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| Authors: | Kojima Naoto Suga Yuki Hayashi Hiromi Yamori Takao Yoshimitsu Takehiko Tanaka Tetsuaki |
| Affiliation: | Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. kojima@phs.osaka-u.ac.jp |
| Abstract: | The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines. |
| Keywords: | Annonaceous acetogenin Structure-activity relationship Antitumor agent Fluorinated analogue Chemical synthesis |
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