Stochastic models for X chromosome inactivation |
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Authors: | Victor E. Kane |
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Affiliation: | (1) Mathematics and Statistics Research Department, Computer Science Division, Union Carbide Corporation, Nuclear Division, 37830 Oak Ridge, Tennessee, USA |
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Abstract: | Summary A multivariate Gaussian model for mammalian development is presented with the associated biological and mathematical assumptions. Many biological investigations use the female mammal X chromosome to test hypotheses and to estimate parameters of the developmental system. In particular, Lyon's (1961) hypotheses are used as a basis of the mathematical model. Experimental mouse data and three sets of human experimental data are analyzed using the hypothesized Gaussian model. The estimated biological parameters are consistent with some current biological theories. |
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Keywords: | Cattanach translocation Cell pool sizes Developmental model Gaussian model Lyon's hypothesis X chromosome X inactivation |
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