RFLPs and linkage relationships of the human laminin B2 gene |
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| Authors: | D Nishimura K H Buetow Y Yamada J C Murray |
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| Institution: | Department of Pediatrics, University of Iowa, Iowa City 52242. |
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| Abstract: | RFLPs for laminin B2 (LAMB2) are reported. These RFLPs were used to study the linkage relationships of LAMB2 to four other genes on lq: Duffy (FY), renin (REN), decay accelerating factor (DAF), and complement receptor 2 (CR2). Multipoint linkage analysis placed LAMB2 between FY and the cluster including REN, DAF, and CR2. This provides a useful bridging polymorphic marker on lq and establishes significant linkage of LAMB2 to FY (theta = 3.23, z = 3.85) and REN (theta = 0.17, z = 4.88). |
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