Habropetaline A,an antimalarial naphthylisoquinoline alkaloid from Triphyophyllum peltatum |
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Authors: | Bringmann Gerhard Messer Kim Schwöbel Babett Brun Reto Aké Assi Laurent |
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Affiliation: | Institut für Organische Chemie der Universit?t, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de |
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Abstract: | The isolation, structural elucidation, and antiprotozoal activities of habropetaline A, a novel naphthylisoquinoline alkaloid from Triphyophyllum peltatum, are described. This alkaloid had previously only been identified on line, by the LC-MS/MS-NMR-CD triad, in the crude extract of the rare and difficult-to-provide related plant species Habropetalum dawei, whose small quantities available had not permitted to isolate the compound. As predicted by quantitative structure-activity relationship (QSAR) investigations, habropetaline A exhibits strong antimalarial activity against Plasmodium falciparum, while it is inactive against other protozoal pathogens (Trypanosoma brucei rhodesience, T. cruzi, and Leishmania donovani). |
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Keywords: | Triphyophyllum peltatum Dioncophyllaceae Habropetaline A Structural elucidation Stereochemistry Antimalarial activity |
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