Calcium oscillation associated with reduced protein kinase C activities in ras-transformed NIH3T3 cells |
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| Authors: | T Fu Y Sugimoto T Oki S Murakami Y Okano Y Nozawa |
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| Affiliation: | Department of Biochemistry, Gifu University School of Medicine, Japan. |
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| Abstract: | We show here novel intracellular Ca2+ oscillation in v-K-ras-transformed NIH3T3 cells induced by mitogenic peptide hormones, bradykinin and bombesin, as well as fetal calf serum. Induction of the Ca2+ oscillation is strongly correlated with the malignant properties and inversely with PKC activities in vitro and in vivo. These results suggest that the mitogen-induced Ca2+ oscillation is negatively regulated by PKC, which modulates Ca2+ influx in v-K-ras-transformed NIH3T3 cells. |
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