A mouse Y Chromosome pseudogene is related to human ubiquitin activating enzyme E1 |
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Authors: | Priscilla K. Tucker Kimberly S. Phillips Barbara Lundrigan |
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Affiliation: | (1) The Museum of Zoology, University of Michigan, 48 109 Ann Arbor, Michigan, USA;(2) Department of Biology, University of Michigan, 48 109 Ann Arbor, Michigan, USA |
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Abstract: | A 2041 bp DNA fragment isolated from the Sxr (sex reversed) region of the mouse Y Chromosome (Chr) was sequenced and characterized. The sequence, pY8/b, contains four exons that are highly similar to 525 contiguous bases from the cDNA of human ubiquitin activating enzyme El. Two of the exons contain stop codons, indicating that pY8/b is not part of a functional gene. Sequences related to pY8/b were amplified from the Y Chr of the inbred mouse strain, C57BL/6J. These sequences may be portions of the recently discovered functional equivalent of pY8/b. Despite a high degree of similarity with the human El gene, the functional equivalent of pY8/b is not the mouse El gene, because unlike El, the functional equivalent of pY8/b is expressed in a tissue-specific manner. These data are discussed with respect to theory on the evolution of the mammalian Y Chr, and in particular, to the prediction that functional genes on the Y Chr have a male-specific function. |
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