不同周龄SD大鼠脏器重量及其变化趋势分析

目的分析不同周龄SD大鼠的脏器重量及其变化趋势,为评判药物毒性反应提供理论参考。方法分别选取试验第13、26、52、78和104周对照组动物脑、脾脏、心脏、肺脏、肝脏、肾脏、肾上腺、睾丸、卵巢的重量数据并分析。结果从13～104周SD雌鼠脑、脾脏、心脏、肺脏、肝脏、肾脏、肾上腺、卵巢的重量呈升高趋势。从13～104周SD雄鼠脑、脾脏、心脏、肺脏、肝脏、肾脏重量均重于雌鼠,但雌鼠肾上腺重量、脏体比和脏脑比均显著高于雄鼠。结论本研究首次在国内建立了符合我国实验动物现状的,不同周龄SD大鼠的脏器重量背景数据和参考值范围,并分析了不同周龄SD大鼠脏器重量变化趋势。

Analysis on Organ Weights and Their Changes Trend in Sprague Dawley Rats with Different Ages

Objective To analyzing organ weights and their changes trend of SD rats with different ages and to provide theoretical reference for evaluating drug toxicity effect.Methods Weights data of brain,spleen,heart,lungs,liver,kidneys,adrenal glands,testis and ovaries from control group SD rats with 13 weeks,26 weeks,52 weeks,78 weeks and 104 weeks ages was obtained.These weights data and their coefficients were analyzed.Results Weights of brain,spleen,heart,lungs,liver,kidneys,adrenal glands and ovaries were increased in female rats from 13 to 104 weeks.Weights of brain,spleen,heart,lungs,liver and kidneys of male rats were higher than that of female rats,whereas adrenal weights,its organ weight /body weight ratio and organ weight/ body weight ratio were significantly higher than that of males from 13 to 104 weeks.Conclusions This study firstly established different week~old SD rats organ weight background data and their reference range which in line with experimental animal status in our country and summarized their changes trend.