| 胚胎肾分支形态发生调控因素 |
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| 引用本文： | 王伟玲,杨宝学. 胚胎肾分支形态发生调控因素[J]. 中国实验动物学杂志, 2012, 0(3): 40-44 |
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| 作者姓名： | 王伟玲 杨宝学 |
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| 作者单位： | 北京大学基础医学院药理学系,分子心血管学教育部重点实验室,北京100191 |
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| 基金项目： | 国家自然科学基金资助项目（No.30870921 81170632）; 高等学校博士学科点专项科研基金（20100001110047） |
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| 摘 要： | 胚胎肾发育最初阶段是中肾导管尾端在胶质细胞源性神经营养因子诱导下向背侧长出输尿管芽,而后成纤维细胞生长因子、肝细胞生长因子、骨形成蛋白、基质金属蛋白酶、整合素和粘附分子相继表达,作用于输尿管芽和间充质细胞,诱导分支形态发生,包括输尿管芽向间充质侵入、延伸以及间充质细胞向上皮转化。上述这些分子在功能上存在部分重叠与拮抗,维持细胞增殖和分化的平衡,从而保证输尿管芽形成正常的分支结构。本文对肾脏发育时期分支形态发生的调控因素进行综述。
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| 关 键 词： | 肾脏发育 分支形态发生 生长因子 整合素 粘附分子 |
Regulation of Branching Morphogenesis in Kidney Development |
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| WANG Wei-ling,YANG Bao-xue. Regulation of Branching Morphogenesis in Kidney Development[J]. Chinese Journal of Laboratory Animal Science, 2012, 0(3): 40-44 |
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| Authors: | WANG Wei-ling YANG Bao-xue |
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| Affiliation: | (Department of Pharmacology,School of Basic Medical Sciences,Peking University,Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education,Beijing 100191,China) |
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| Abstract: | Development of the kidney is initiated when the caudal region of the Wolffian duct（WD） swells and then buds out into the adjacent metanephric mesenchyme（MM） induced by GDNF.Then FGF,HGF,BMP,MMP,integrin and adhesion molecules are expressed in the UB and MM result in branching morphogenesis,including the ureteric bud（UB） invation into the MM,the elongation of the UB and mesenchymal-epithelial transition（MET）.Those molecules function in maintaining a balance of cell proliferation and differentiation to ensure normal formation of the branches.Also,there are parts of overlap and antagonist between those growth factors.This review focuses on the regulation of branching morphogenesis. |
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| Keywords: | Kidney development Branching morphogenesis Growth factor Integrin Adhesion molecule |
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