| HIV超感染防御研究进展 |
| |
| 引用本文： | 熊竞,丛喆,魏强.HIV超感染防御研究进展[J].中国实验动物学杂志,2012(3):61-64. |
| |
| 作者姓名： | 熊竞 丛喆 魏强 |
| |
| 作者单位： | 中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021 |
| |
| 基金项目： | 国家十二五科技重大专项课题（2012ZX10004-501 2012ZX10001-006） |
| |
| 摘 要： | 机体在原发感染病毒后,体内能产生某种可能的干扰以阻挡、防止被同种（或同类别）株病毒再次感染现象,HIV感染中也存在这种超感染防御现象。显然,该的研究对于改进HIV疫苗研制策略及其他抗病毒策略十分重要。目前研究认为感染细胞在分子水平上产生的超感染抵抗（superinfection resistance,SIR）和机体免疫反应是感染个体能防御超感染的主要原因。但以上各种假说都没有得到充分验证,HIV超感染防御依然尚未明确。本文将这些研究进行总结,以期找出新的突破口,推进该项研究。
|
| 关 键 词： | HIV 超感染抵抗（SIR） CD4下调 |
Introduction to the Superinfection with HIV Infection |
| |
| XIONG Jing,CONG Zhe,WEI Qiang.Introduction to the Superinfection with HIV Infection[J].Chinese Journal of Laboratory Animal Science,2012(3):61-64. |
| |
| Authors: | XIONG Jing CONG Zhe WEI Qiang |
| |
| Institution: | (Key Laboratory of Human Diseases Comparative Medicine,Ministry of Health;Institute of Medical Laboratory Animal Science,Chinese Academy of Medical Sciences;Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine;Peking Union Medicine College,Beijing 100021,China) |
| |
| Abstract: | The retroviral phenomenon of superinfection resistance defines an interference mechanism that is established after primary infection,and provides possible protection against the challenge with the same virus.A better knowledge of superinfection resistance-induced mechanisms could be useful for the development of an HIV vaccine or other antiviral strategies.Present studies suggest that the SIR based on infected cells and the immune response in vivo were concluded to be the main possible reasons for the protection against superinfection.However,so far the real mechanism in protecting patients from HIV superinfection has not been studied throughly.This paper reviews the findings and introduces the updates of superinfection with HIV infection. |
| |
| Keywords: | HIV Superinfection resistance SIR CD4 downregulation |
| 本文献已被 维普 等数据库收录！ |
|
