Biophysical and biochemical properties of oligodeoxy-nucleotides containing 4'-C- and 5'-C-substituted thymidines |
| |
| Authors: | Wang G Middleton P J Lin C Pietrzkowski Z |
| |
| Institution: | Research Department, ICN Pharmaceuticals, Inc., Costa Mesa, CA 92626, USA. |
| |
| Abstract: | We have previously reported oligodeoxynucleotides (ODNs) containing 4'-C- and 5'-C-substituted thymidines, which demonstrated certain favorable biophysical and biochemical properties. In this communication, the hybridization and nuclease stability data of the ODNs along with their capability to induce RNase H activity are presented. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
