Quantitative analysis of the antiviral activity of CD8(+) T cells from human immunodeficiency virus-positive asymptomatic patients with different rates of CD4(+) T-cell decrease |
| |
Authors: | Salerno-Gonçalves R Lu W Andrieu J M |
| |
Affiliation: | Laboratoire d''Oncologie et Virologie Moleculaire, Faculté Necker, Hôpital Laennec, 75340 Paris Cedex 07, France |
| |
Abstract: | We have measured in 22 asymptomatic human immunodeficiency virus type 1-infected patients (10 rapid progressors and 12 slow progressors) the proviral load of CD4(+) T cells homogeneously superinfected by the same dose of a non-syncytium-inducing virus in the presence or in the absence of autologous CD8(+) T cells. We demonstrated that the antiviral activity of CD8(+) T cells was highly predictive of the rate of peripheral CD4(+) T-cell decline. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |