Increased methotrexate-induced chromosome breakage in patients with free trisomy 21 and their parents |
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| Authors: | Lothar Pelz Jürgen Götz Gabriele Krüger Gabriele Witt |
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| Institution: | (1) Abteilung für Neonatologie und Klinische Genetik, Universitäts-Kinderklinik, Wilhelm-Pieck Universität, DDR-2500 Rostock 1, German Democratic Republic;(2) Rembrandstrasse 16/17, DDR-2500 Rostock 1, German Democratic Republic |
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| Abstract: | Summary Increased susceptibility of chromosomes from peripheral blood lymphocytes to the antimetabolite methotrexate (2×10-6
M) has been found in patients with free trisomy 21 and their parents (N=14). The level of induced chromatid and chromosome breaks is lowest in normal controls intermediate in patients' mothers and fathers, and highest in trisomy 21 patients. The findings are viewed as a special type of cytogenetic polymorphism or as a defective chromosomal infrastructure, also in the parents of trisomic children.Dedicated to Professor Dr. H.A. Freye, Halle/Saale, in honor of his 65th birthday |
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