Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus |
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Authors: | Guerrero-Plata Antonieta Casola Antonella Garofalo Roberto P |
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Institution: | Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA. |
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Abstract: | Lung cytokine and chemokine production by BALB/c mice infected with human metapneumovirus (hMPV) was compared to respiratory syncytial virus (RSV)-infected mice. hMPV infection induced lower levels of the inflammatory cytokines interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha but was a more potent inducer of granulocyte-macrophage colony-stimulating factor and triggered a more sustained production of the CXC chemokine KC compared to RSV. hMPV was a stronger inducer of both alpha interferon (IFN-alpha) and IFN-gamma responses than RSV. In regard to immunomodulatory cytokines, hMPV failed to induce detectable IL-10 or IL-12p70 but was a potent inducer of IL-12 p40 subunit. The implications for hMPV pathogenesis are discussed. |
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