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Effect of a cold stimulus on the synthesis of uncoupling protein in brown adipose tissue of rats and newborn rabbits |
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| Authors: | John Arnold Hasmukh V Patel Robert G Ridley Karl B Freeman |
| Institution: | (1) Department of Biochemistry, McMaster University, 1200 Main Street West, L8N 3Z5 Hamilton, Ontario, Canada;(2) Department of Pediatrics, McMaster University, 1200 Main Street West, L8N 3Z5 Hamilton, Ontario, Canada;(3) Present address: Royal North Shore Hospital, 2065 St. Leonards, New South Wales, Australia |
| Abstract: | Rats are known to respond to a cold stimulus by increasing the activity and amount of the uncoupling protein in brown adipose tissue. A 48 h cold stimulus was found to increase the synthesis of uncoupling protein 3.g-fold in 4–5 week old rats whereas no change was observed with newborn rabbits. The lack of response in the latter case may reflect a difference between rabbits and rats or that synthesis is already maximal in newborn rabbits. |
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