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| 膜脂物理属性及化学成分对BKCa钾离子通道的调节作用 | |
| 引用本文： | 雷涛,黄美燕,邓爱红,戚智. 膜脂物理属性及化学成分对BKCa钾离子通道的调节作用[J]. 生物物理学报, 2008, 24(1): 1-5 |
| 作者姓名： | 雷涛 黄美燕 邓爱红 戚智 |
| 作者单位： | 1. 四川大学物理科学与技术学院应用物理系,成都,610065;中国科学院生物物理研究所,脑与认知科学国家重点实验室,北京100101 2. 中国科学院生物物理研究所,脑与认知科学国家重点实验室,北京,100101 3. 四川大学物理科学与技术学院应用物理系,成都,610065 |
| 基金项目： | 国家自然科学基金项目(30470447) |
| 摘 要： | 大电导钙激活电压门控型钾离子通道(BKCa通道)广泛分布于各种组织中,主要由胞内钙离子浓度增加和细胞膜去极化而激活.此外多种膜脂,如脂肪酸、胆固醇、鞘糖脂等可修饰该通道的功能.该通道参与细胞内信号转导、细胞的兴奋及代谢调节等多种生理过程,其功能异常牵涉到特发性癫痫、高血压等疾病的发生.因而对BKCa通道功能的调节作用的研究具有重要的生理学及病理学意义.文章将主要介绍膜脂对BKCa通道功能的调节作用. |
| 关 键 词： | BKCa通道 膜脂 脂肪酸 胆固醇 鞘糖脂 膜脂 物理属性 化学成分 钾离子通道 调节作用 CHANNELS MEMBRANE LIPIDS 意义 病理学 生理学 研究 发生 疾病 高血压 特发性癫痫 功能异常 生理过程 代谢调节 细胞内信号转导 修饰 |
| 收稿时间： | 2007-10-11 |
| 修稿时间： | 2007-10-11 |
MODULATORY EEEFECT OF MEMBRANE LIPIDS ON BKCa CHANNELS |
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| LEI Tao,HUANG Mei-yan,DENG Ai-hong,QI Zhi. MODULATORY EEEFECT OF MEMBRANE LIPIDS ON BKCa CHANNELS[J]. Acta Biophysica Sinica, 2008, 24(1): 1-5 | |
| Authors: | LEI Tao HUANG Mei-yan DENG Ai-hong QI Zhi |
| Affiliation: | 1. Department of Applied Physics, School of Physics Science and technology, University of Sichuan, Chengdu 610065, China; 2. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, CAS, Beijing 100101, China |
| Abstract: | The large-conductance, voltage-gated and calcium-activated potassium channels (BKCa) are involved in many cellular functions. They are activated both by elevated cytosolic Ca2+ levels and membrane depolarization. Recently, it has been reported that the BKCa channels are regulated by many types of membrane lipids, such as fatty acids, cholesterol, and glycosphingolipids. The dysfunctions of BKCa channels are associated with various diseases such as idiopathic epilepsy, hypertension and stroke. Therefore, it is import to study how the BKCa channels are modulated. This review focuses on modulatory effect of membrane lipids on BKCa channels. |
| Keywords: | BKCa channels Membrane lipids Fatty acids Cholesterol Glycosphingolipids |
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