Human urokinase contains GalNAc beta (1-4)[Fuc alpha (1-3)]GlcNAc beta (1-2) as a novel terminal element in N-linked carbohydrate chains. |
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| Authors: | A A Bergwerff J E Thomas-Oates J van Oostrum J P Kamerling J F Vliegenthart |
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| Institution: | Bijvoet Center, Department of Bio-Organic Chemistry, Utrecht University, The Netherlands. |
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| Abstract: | Structural analysis of enzymically released N-linked carbohydrate chains of human urokinase (urinary-type plasminogen activator) by 1H NMR spectroscopy and FAB-MS demonstrated that the N-linked oligosaccharides on the only N-glycosylation site contain diantennary structures with the novel GalNAc beta (1-4) Fuc alpha (1-3)]GlcNAc beta (1-2) element in the upper or the lower branch. |
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