| p53和c-myc异常表达与胃癌细胞多药耐药性关系的研究 |
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| 引用本文： | 刘勇,路名芝,李启明,王夷黎. p53和c-myc异常表达与胃癌细胞多药耐药性关系的研究[J]. 中国组织化学与细胞化学杂志, 1997, 0(1) |
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| 作者姓名： | 刘勇 路名芝 李启明 王夷黎 |
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| 作者单位： | 江西省人民医院病理科 |
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| 摘 要： | 应用ＳＡＢＣ免疫组织化学方法研究６７例胃标本中ｐ５３和ｃ－ｍｙｃ的表达与多药耐药性（ＭＤＲ）的关系。结果显示本组胃癌中ｐ５３阳性３２例，阳性率４７．８％；ｃ－ｍｙｃ阳性３７例，阳性率５５．２％；Ｐ－ｇｐ阳性３９例，阳性率５８．２％。ｐ５３的异常表达与ｍｄｒ－１基因表达呈显著正相关（ｒ＝０．６３，Ｐ＜０．０５），而ｃ－ｍｙｃ和ｍｄｒ－１的表达无明显相关。提示ｐ５３异常表达可增加ｍｄｒ－１基因的表达，从而使胃癌细胞获得ＭＤＲ表型
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| 关 键 词： | 胃肿瘤 基因表达 多药耐药性 免疫组织化学 |
A STUDY OF CORRELATION BETWEEN THE ABNORMAL EXPRESSION OF P 53 AND c myc PROTEIN WITH MULTIDRUG RESISTANT IN GASTRIC CANCER |
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| Liu Yong,Lu Mingzhi,Li Qiming,et al.. A STUDY OF CORRELATION BETWEEN THE ABNORMAL EXPRESSION OF P 53 AND c myc PROTEIN WITH MULTIDRUG RESISTANT IN GASTRIC CANCER[J]. Chinese Journal of Histochemistry and Cytochemistry, 1997, 0(1) |
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| Authors: | Liu Yong Lu Mingzhi Li Qiming et al. |
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| Abstract: | Using SABC immunohistochemical methods, the correlation of the expression of p53 and c myc protein with multidrug resistant (MDR) in 67 cases of gastric cancer was studied. The results showed that 32(47 8%) cases of gastric cancer were positive of p53, 37(55 2%) cases of gastric cancer were positive of c myc, 39(58 2%) cases of gastric cancer were positive of P gp. A significant correlation was found between p53 overexpression and mdr 1 gene expression (r=0 63, P <0 05). Meanwhile, there was no significant correlation of the expression of c myc and mdr 1. It is suggested that p53 overexpression might increase the expression of mdr 1 gene, as a result, the gastric cancer produced MDR. |
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| Keywords: | Gastric neoplasms Gene expression Multidrug resistant Immunohistochemistry |
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