The potential of stem cells as an in vitro source of red blood cells for transfusion |
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| Authors: | Migliaccio Anna Rita Whitsett Carolyn Papayannopoulou Thalia Sadelain Michel |
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| Affiliation: | Tisch Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA. annarita.migliaccio@mssm.edu |
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| Abstract: | Recent advances have increased excitement about the potential for therapeutic production of red blood cells (RBCs) in vitro. However, generation of RBCs in the large numbers required for transfusion remains a significant challenge. In this article, we summarize recent progress in producing RBCs from various cell sources, and discuss the hurdles that remain for translation into the clinical arena. |
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