嗜麦芽窄食单胞菌感染危险因素与其耐药特征的研究

目的　研究嗜麦芽窄食单胞菌感染危险因素及其耐药特征,以提高临床对嗜麦芽窄食单胞菌防治水平。方法　对6 8例嗜麦芽窄食单胞菌感染者的临床资料进行统计分析,并用K- B法测其耐药情况。结果　嗜麦芽窄食单胞菌占非发酵革兰阴性杆菌的9.5 2 % ,居铜绿假单胞菌与不动杆菌之后,列第3位。药敏试验表明,该菌广泛耐药,敏感率>5 0 %者仅有复方新诺明、替卡西林-克拉维酸与头孢哌酮-舒巴坦,在感染者中,有85 .3%患者有基础病,98.5 %使用过广谱抗生素,70 .6 %曾接受侵入性检查和治疗。结论　嗜麦芽窄食单胞菌已成为医院感染重要致病菌,多发生在免疫功能低下的老人,慢性疾病、长期疾病、长期接受激素及使用抗菌药物、施行各种侵入性检查和治疗的患者。嗜麦芽窄食单胞菌对多种抗生素耐药,一旦感染,治疗颇为困难

Risk factors for stenotrophomonas maltophilia infection and antimicrobial resistance pattern

Objective To study the risk factors,facilitate prevention and treatment of Stenotrophomonas maltophilia infection and to investigate the antimicrobial resistance pattern of S.maltphilia .Methods 68 cases of S.malthophilia infections were analyzed in this study,and K B method was used to test the susceptibility of isolates to the antimicrobials.Results Of all the non ferment Gram negative bacteria isolated clinically, S.maltophilia was 9 25%,at the third place following P.aeruginosa and Acinetobacter .The majoity of clinical strains of S.maltophilia were multiresistant to antimicrobials,with the exception of SMZ TMP,ticarcillin clavulanate and cefoperazone sulbactam,to which more than 50% strains were susceptible.Of all infected patients, 85.3 % of them underwent primary diseases;98.5% of patients were treated previously with broad spectrum antibiotics;70.6% of them were suffered the intrusive examination and treatment.Conclusions S.maltophilia had become one of the important nosocomial pathogens. S.maltophilia infection was often occurred in immunocompromised individuals,such as the older and the patients who were undergoing chronic diseases,treated with hormone and antibiotics over a long period time.The patients who had undergone the various intrusive examinations and treatments were easily infected.The mutiresistance of S.maltophilia to common antibiotics leads to quite diffculty in treatment of the infected patients.