What we have learned about prokaryotes from structural genomics |
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Authors: | Frishman Dmitrij |
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Affiliation: | Department of Genome Oriented Bioinformatics, Technical University of Munich, Freising-Weihenstephan, Germany. d.frishman@gsf.de |
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Abstract: | Five years ago systematic determination and theoretical analysis of all protein structures encoded in model prokaryotic organisms was proposed as a powerful way to obtain new insights into protein function and the variety of protein folds. What has been the pay-off from studying structures in genomic context? Have we learned anything new about protein structure? Can we now predict protein function better? In this contribution, I summarize the status of large-scale structure determination projects on prokaryotes and provide an overview of the main results obtained from experimental and theoretical studies in this dynamic research field. |
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