| 雾化吸入PS在正常和内毒素性肺损伤兔肺内吸入量及分布 |
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| 引用本文： | 兰和魁. 雾化吸入PS在正常和内毒素性肺损伤兔肺内吸入量及分布[J]. 中国应用生理学杂志, 2000, 16(1): 64-67 |
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| 作者姓名： | 兰和魁 |
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| 作者单位： | [1]第四军医大学附属珠江医院儿科 [2]广州赤岗一七七医院 |
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| 摘 要： | 目的：超声雾化吸入肺表面活性物质（ＰＳ）治疗兔急性肺损伤时，观察ＰＳ肺内吸入量信分布。方法：大肠杆菌内毒素致兔急性肺损伤后，采用＾９９ｍＴｃ－ＤＴＰＡ和ＰＳ混合进行雾化吸入治疗，测定ＳＰ吸入肺内百分比及各种肺野所占比例。结果：流急性肺损伤经超声雾化吸入治疗吸入肺内量（以磷脂汁）正常组、气管插管雾化组、口罩 经组分别为５．３４、７．０１、５．６１ｍｇ／ｋｇ体重，上、中、下肺野极差分别为６．６、１、９
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| 关 键 词： | 超声雾化吸入 急性肺损伤 ET PS NRDS ARDS 分布 |
| 修稿时间： | : |
INSPIRATORY DOSES AND DISTRIBUTIONS OF EXOGENOUS PULMONARY SURFACTANT IN NORMAL AND DAMAGED LUNG INDUCED BY ENDOTOXIN IN RABBITS WITH NEBULIZING |
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| LAN He kui ,FENG Zhi chun ,LI Xiu yun ,PENG Wu he ,et al. INSPIRATORY DOSES AND DISTRIBUTIONS OF EXOGENOUS PULMONARY SURFACTANT IN NORMAL AND DAMAGED LUNG INDUCED BY ENDOTOXIN IN RABBITS WITH NEBULIZING[J]. Chinese journal of applied physiology, 2000, 16(1): 64-67 |
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| Authors: | LAN He kui FENG Zhi chun LI Xiu yun PENG Wu he et al |
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| Affiliation: | LAN He kui 1,FENG Zhi chun 1,LI Xiu yun 2,PENG Wu he 3,et al |
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| Abstract: | Aim: Acute lung injury (ALI) of rabbits was treated by nebulizing exogenous surfactant (PS) to observe inspiratory dose and distribution of PS. Methods:After ALI was induced by endotoxin of E.coli,mixture of 99m Tc DTPA and PS was nebulized. Inhaling percentage and proportion of PS of various areas in pulmonary parenchyma were determined. Results:Inhaling phosphatide doses in three groups (normal,intubation,mask) were 5.34,7.01,5. 61 mg/Kg wt respectively.The range of each group was 6. 6%, 19. 55 ,10.4% between the most and the least in different area and 16. 5%,20. 9%,13. 8% in inner and outer zones respectively.Conclusion:The phospholipid inspired were more than the effective dose in two groups. More quantities were inhaled when using intubation ( P <0.05). The uniformity of mask inhalation is better than that of intubation ( P <0.01). |
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| Keywords: | nebulize PS acute lung injury Newzealand rabbits |
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