High cell density and latent membrane protein 1 expression induce cleavage of the mixed lineage leukemia gene at 11q23 in nasopharyngeal carcinoma cell line |
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Authors: | Peter Han-Chung Yee Sai-Peng Sim |
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Institution: | (1) Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Lot 77, Seksyen 22 KTLD, Jalan Tun Ahmad Zaidi Adruce, 93150 Kuching, Sarawak, Malaysia |
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Abstract: | Background Nasopharyngeal carcinoma (NPC) is commonly found in Southern China and South East Asia. Epstein-Barr virus (EBV) infection
is well associated with NPC and has been implicated in its pathogenesis. Moreover, various chromosome rearrangements were
reported in NPC. However, the underlying mechanism of chromosome rearrangement remains unclear. Furthermore, the relationship
between EBV and chromosome rearrangement with respect to the pathogenesis of NPC has not been established. We hypothesize
that during virus- or stress-induced apoptosis, chromosomes are initially cleaved at the base of the chromatin loop domain
structure. Upon DNA repair, cell may survive with rearranged chromosomes. |
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