Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs |
| |
| Authors: | Srivastav Naveen C Shakya Neeraj Bhavanam Sudha Agrawal Amogh Tse Chris Desroches Nancy Kunimoto Dennis Y Kumar Rakesh |
| |
| Institution: | Department of Laboratory Medicine and Pathology, 1-71 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7. |
| |
| Abstract: | Several 5-alkyl (or halo)-3'-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3'-azido-5-ethyl-2',3'-dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC(50)=1μg/mL), M. tuberculosis (MIC(50)=10μg/mL) and M. avium (MIC(50)=10μg/mL). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
