Institute of General Biology, University of Siena and the Centro per to Studio delle Cellule Germinali, C.N.R., Siena, Italy
Abstract:
This report describes the “crater defect” in human spermatozoa, a malformation that consists of a nuclear and acrosomal invagination present in 100% of the cells, whereas tail structure and motility are fairly normal. The defect occurs during spermiogenesis. A possible concomitance with abnormalities in the microtubular apparatus involved in the sperm molding is discussed.