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Crater defect in human spermatozoa
Authors:Professor B. Baccetti  A. G. Burrini  G. Collodel  A. R. Magnano  P. Piomboni  T. Renieri  C. Sensini
Affiliation:Institute of General Biology, University of Siena and the Centro per to Studio delle Cellule Germinali, C.N.R., Siena, Italy
Abstract:This report describes the “crater defect” in human spermatozoa, a malformation that consists of a nuclear and acrosomal invagination present in 100% of the cells, whereas tail structure and motility are fairly normal. The defect occurs during spermiogenesis. A possible concomitance with abnormalities in the microtubular apparatus involved in the sperm molding is discussed.
Keywords:human spermatozoa  “crater defect,”  nuclear malformation  acrosome malformation  cytoskeleton  sperm head morphogenesis
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