Determination of Ki67 Growth Fraction and Oestrogen Receptors In Screen-Detected Breast Cancer Using Cytological Preparations |
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Authors: | R. CODDINGTON A. CUTHBERT I. D. CAMPBELL A. HERBERT J. M. THEAKER G. T. ROYLE I. TAYLOR |
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Affiliation: | 1. Southampton and Salisbury Breast Screening Unit, Royal South Hants Hospital, Department of Pathology;2. University Surgical Unit, Southampton General Hospital, Southampton, UK |
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Abstract: | Oestrogen receptor (ER) status of 77 cases of screen-detected breast cancer has been determined using cytological preparations. In 48% ER status was positive, which was the same proportion as that formed in a control group of age-matched patients with symptomatic breast carcinoma. Since the screen-detected group contained more low grade tumours, the percentage of ER-positive cases would be expected to be higher. the reasons for the discrepancy are discussed. Ki67 score has been determined for 41 cases of screen-detected cancer. Ki67 score showed a positive correlation with histological tumour grade and a negative correlation with ER status. However, there was no correlation with tumour size or lymph node status. the Ki67 scores in the screen-detected cancers were essentially similar to those found in an age-matched symptomatic group, but the very low scores were only found in the screened group. |
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Keywords: | breast carcinoma oestrogen receptors monoclonal antibody Ki67 immuno-cytochemistry fine needle aspiration cytology |
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