Short communication: Mapping of two tumor suppressor genes in the pig |
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| Authors: | K. A. Kelly N. J. Larsen S. Marklund M. F. Rothschild |
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| Affiliation: | 1. Department of Animal Science , Iowa State University , Ames, 50011;2. Dept. of Animal Science , Iowa State University , Ames, IA, 50011 Phone: (515) 924‐6202 Fax: (515) 924‐6202 |
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| Abstract: | Abstract Mutations in the breast cancer 1, early onset (BRCA1) gene confer an increased risk of breast and ovarian cancer in humans. The human MAD (mothers against decapentaplegic, Drosophila) homolog 4 (MADH4) locus is a target for deletion in pancreatic and other cancers. Given the role of the pig in biomedical studies, pig orthologs of BRCAl and MADH4 were identified and localized in the porcine genome. |
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