Antimutagenic activity against trp-P-1 of the edible Thai plant, Oroxylum indicum vent. |
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| Authors: | K Nakahara M Onishi-Kameyama H Ono M Yoshida G Trakoontivakorn |
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| Affiliation: | Japan International Research Center for Agricultural Sciences (JIRCAS), Tsukuba, Ibaraki. knakahar@affrc.go.jp |
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| Abstract: | A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC50 value of 2.78+/-0.15 microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+/-0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2. |
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