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Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria |
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| Authors: | Hanessian Stephen Pachamuthu Kandasamy Szychowski Janek Giguère Alexandre Swayze Eric E Migawa Michael T François Boris Kondo Jiro Westhof Eric |
| Affiliation: | Department of Chemistry, Université de Montréal, Montréal, Canada. stephen.hanessian@umontreal.ca |
| Abstract: | Incorporation of an hydrophobic (phenethylamino)ethyl ether at C2″ of N1-(HABA)-3',4'-dideoxyparomomycin led to a novel analog with an excellent antibacterial profile against a host of resistant bacteria. |
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