|
|||||
|
|
Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice |
|
| Authors: | Ying Cheng Jicong Du Ruling Liu Suhe Dong Jianming Cai Fu Gao Cong Liu |
| Institution: | 1. Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China
Contribution: ?Investigation (equal), Methodology (equal);2. Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China;3. Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China Contribution: Formal analysis (supporting);4. Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China Contribution: Methodology (supporting);5. Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China Contribution: Resources (supporting) |
| Abstract: | Severe ionizing radiation causes the acute lethal damage of haematopoietic system and gastrointestinal tract. Here, we found CL429, the novel chimeric TLR2/NOD2 agonist, exhibited significant radioprotective effects in mice. CL429 increased mice survival, protected mice against the lethal damage of haematopoietic system and gastrointestinal tract. CL429 was more effective than equivalent amounts of monospecific (TLR2 or NOD2) and combination (TLR2 + NOD2) of molecules in preventing radiation-induced death. The radioprotection of CL429 was mainly mediated by activating TLR2 and partially activating NOD2. CL429-induced radioprotection was largely dependent on the activation of TLR2-MyD88-NF-κB signalling pathway. In conclusion, the data suggested that the co-activation of TLR2 and NOD2 could induce significant synergistic radioprotective effects and CL429 might be a potential high-efficiency selective agent. |
| Keywords: | Cl429 NOD2 radiation radioprotection TLR2 |