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CircPUM1 promotes hepatocellular carcinoma progression through the miR-1208/MAP3K2 axis |
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| Authors: | Yaqiong Zhang Dongguo Wang Tao Zhu Jin Yu Xiaoyu Wu Weidong Lin Minqi Zhu Yingjie Dai Jie Zhu |
| Affiliation: | 1. Department of Clinical Laboratory, Taizhou Central Hospital (Taizhou University Hospital), Zhejiang, China;2. Department of Clinical Lab Medicine, Taizhou Municipal Hospital Affiliated with Taizhou University, Zhejiang, China Contribution: Methodology (equal), Writing - original draft (equal);3. Department of Plastic surgery, Taizhou Central Hospital (Taizhou University Hospital), Zhejiang, China Contribution: Formal analysis (equal);4. The Health Management Centre, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China Contribution: Formal analysis (equal);5. Department of Clinical Laboratory, Taizhou Central Hospital (Taizhou University Hospital), Zhejiang, China Contribution: Data curation (equal), Investigation (equal), Writing - original draft (equal);6. Department of Clinical Laboratory, Taizhou Central Hospital (Taizhou University Hospital), Zhejiang, China Contribution: Software (equal), Validation (equal);7. Department of Clinical Laboratory, Taizhou Central Hospital (Taizhou University Hospital), Zhejiang, China Contribution: Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - original draft (equal);8. Department of Clinical Laboratory, Taizhou Central Hospital (Taizhou University Hospital), Zhejiang, China Contribution: Project administration (equal), Writing - original draft (equal) |
| Abstract: | Hepatocellular carcinoma (HCC) is a common disease with a significant mortality, and there is no effective treatment for advanced patients. Growing evidence indicates that circRNAs are closely related to HCC progression, may be used as biomarkers and targets for the diagnosis and treatment of HCC. Recent researches have shown that circPUM1 may play an oncogene role in a variety of human cancers, but its role in HCC development has not been reported. Our study found that circPUM1 could promote the proliferation, migration and invasion of HCC cells in vitro. In addition, in vivo studies showed that circPUM1 could increase the development of HCC tumours and regulate the expression of EMT-related proteins. Furthermore, we demonstrated that circPUM1 could promote the development of HCC by up-regulating the expression of MAP3K2 via sponging miR-1208. Our study suggested that circPUM1 may be a potential therapeutic target for HCC. |
| Keywords: | circPUM1 hepatocellular carcinoma MAP3K2 miR-1208 |