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Innate lymphoid cells are double-edged swords under the mucosal barrier |
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| Authors: | Zhen Duan Mandie Liu Lin Yuan Xizi Du Mengping Wu Yu Yang Leyuan Wang Kai Zhou Ming Yang Yizhou Zou Yang Xiang Xiangping Qu Huijun Liu Xiaoqun Qin Chi Liu |
| Institution: | 1. Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, China
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Investigation (equal), Resources (equal), Writing - original draft (equal), Writing - review & editing (equal);2. Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, China Contribution: Data curation (equal), Resources (equal), Writing - original draft (equal), Writing - review & editing (equal);3. Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, China Contribution: Resources (equal);4. Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW, Australia Contribution: Resources (equal), Supervision (equal);5. Department of Immunology, School of Basic Medicine Science, Central South University, Changsha, China Contribution: Resources (equal), Supervision (equal);6. Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, China Contribution: Funding acquisition (equal), Supervision (equal);7. Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, China Contribution: Project administration (equal), Supervision (equal);8. Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, China |
| Abstract: | As the direct contacting site for pathogens and allergens, the mucosal barrier plays a vital role in the lungs and intestines. Innate lymphoid cells (ILCs) are particularly resident in the mucosal barrier and participate in several pathophysiological processes, such as maintaining or disrupting barrier integrity, preventing various pathogenic invasions. In the pulmonary mucosae, ILCs sometimes aggravate inflammation and mucus hypersecretion but restore airway epithelial integrity and maintain lung tissue homeostasis at other times. In the intestinal mucosae, ILCs can increase epithelial permeability, leading to severe intestinal inflammation on the one hand, and assist mucosal barrier in resisting bacterial invasion on the other hand. In this review, we will illustrate the positive and negative roles of ILCs in mucosal barrier immunity. |
| Keywords: | epithelial cells innate lymphoid cells (ILCs) mucosal barrier mucosal diseases |