|
|||||
|
|
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis |
|
| Authors: | Yang Yang Anna Han Xinyue Wang Xianglin Yin Minghua Cui Zhenhua Lin |
| Affiliation: | 1. Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, China Key Laboratory of the Science and Technology Department of Jilin Province, Yanji, China Contribution: Data curation (equal), Formal analysis (equal), Project administration (equal), Resources (equal);2. Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, China Key Laboratory of the Science and Technology Department of Jilin Province, Yanji, China Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal);3. Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, China;4. Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, China Key Laboratory of the Science and Technology Department of Jilin Province, Yanji, China Contribution: Writing - review & editing (equal);5. Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, China Key Laboratory of the Science and Technology Department of Jilin Province, Yanji, China Contribution: Supervision (equal) |
| Abstract: | Human hydroxysteroid dehydrogenase-like 2 (HSDL2) is a potent regulator in cancers and is also involved in lipid metabolism, but the role of HSDL2 in cervical cancer and whether it regulates the progress of cervical cancer through lipid metabolism remains unclear. In this study, we found that the overexpression of HSDL2 was in relation with cervical cancer progression including lymph nodes metastasis and recurrence. HSDL2 could serve as a novel marker of early diagnosis in cervical cancer. HSDL2 also gave impetus to tumorigenesis by initiating and promoting proliferation, invasion and migration of cervical cancer cells (Hela, C33A and SiHa) through EMT. Interestingly, we also searched that HSDL2 participated in oncogenesis by regulating lipid metabolism. In sum, our results gave the novel insight of HSDL2 functions which could be the potential for being the biomarker of prognosis and new target of therapy. |
| Keywords: | cervical cancer EMT HSDL2 lipid metabolism prognosis |