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Interactions of anthropometric indices,rs9939609 FTO gene polymorphism and breast cancer: A case-control study |
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| Authors: | Saeid Doaei Fatemeh Bourbour Samira Rastgoo Mohammad Esmail Akbari Maryam Gholamalizadeh Azadeh Hajipour Alireza Moslem Fereshteh Ghorat Mostafa Badeli Seyedeh Elaheh Bagheri Atieh Alizadeh Zohreh Mokhtari Samaneh Pishdad Sepehr JavadiKooshesh Ghasem Azizi Tabesh Fateme Montazeri Parvin Joola Shahla Rezaei Masoomeh Dorosti Seyed Alireza Mosavi Jarrahi |
| Institution: | 1. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Science, Tehran, Iran
Contribution: Methodology (equal), Validation (equal);3. Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Science, Tehran, Iran Contribution: ?Investigation (equal);4. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Contribution: ?Investigation (equal), Methodology (equal), Supervision (equal);5. Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Contribution: Data curation (equal), Formal analysis (equal);6. Department of Health Sciences in Nutrition, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran Contribution: Data curation (equal), Validation (equal);7. Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran Contribution: Visualization (equal), Writing - original draft (equal);8. Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran Contribution: ?Investigation (equal);9. Department of Nutrition, Urmia University of Medical Science, Urmia, Iran Contribution: Resources (equal);10. School of Paramedicine, Guilan University of Medical Sciences, Langroud, Iran Contribution: Validation (equal);11. Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Science, Tehran, Iran Contribution: Methodology (equal), Writing - review & editing (equal);12. Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Contribution: Visualization (equal);13. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Contribution: Writing - original draft (equal);14. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Contribution: Methodology (equal);15. Genomic Research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Contribution: ?Investigation (equal);16. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Contribution: Visualization (equal);17. Department of non-communicable diseases, deputy of health services, Dezful University of Medical Sciences, Dezful, Iran Contribution: Methodology (equal), Validation (equal);18. Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Contribution: Data curation (equal);19. Department of Nutrition, Urmia University of Medical Science, Urmia, Iran Contribution: Methodology (equal), Supervision (equal) |
| Abstract: | Contradictory results were reported on the effect of fat mass- and obesity-associated (FTO) gene and anthropometric measurements on breast cancer (BC). This study aimed to assess the interactions between rs9939609 polymorphism of FTO gene, anthropometric indices and BC risk in Iranian women. This case-control study was performed on 540 women including 180 women with BC and 360 healthy women in Tehran, Iran. Physical activity and dietary intakes were assessed by validated questionnaires. Data on sociodemographic and pathologic factors of the participants as well as their blood samples were collected. The rs9939609 FTO gene polymorphism was genotyped using the tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). No significant association was found between BC and risk allele of FTO rs9939609 polymorphism after adjustments for the confounders. However, there was a significant association between rs9939609 polymorphism risk allele and BC risk in females with overweight, even after adjusting for age, family history of BC, abortion, BMI and the number of pregnancies (P < .05). The association was disappeared after further adjustments for lifestyle factors including smoking, alcohol consumption, calorie and macronutrients intake, and physical activity. The FTO gene polymorphism was associated with the risk of BC in overweight individuals. This association was influenced by environmental factors including diet, alcohol consumption and smoking. Future studies are required to confirm the association between the FTO gene and BC in overweight females and to identify the underlying mechanisms. |
| Keywords: | anthropometric indices breast cancer fat mass- and obesity-associated polymorphism |