|
|||||
|
|
Sestrin2 as a gatekeeper of cellular homeostasis: Physiological effects for the regulation of hypoxia-related diseases |
|
| Authors: | Cunyao Pan Zhaoli Chen Chao Li Tie Han Hui Liu Xinxing Wang |
| Institution: | 1. Tianjin Institute of Environmental and Operational Medicine, Tianjin, China
Department of Public Health, Lanzhou University, Lanzhou, China Contribution: Conceptualization (lead), Visualization (lead), Writing - review & editing (lead);2. Tianjin Institute of Environmental and Operational Medicine, Tianjin, China Contribution: Writing - review & editing (supporting);3. Tianjin Institute of Environmental and Operational Medicine, Tianjin, China;4. Department of Public Health, Lanzhou University, Lanzhou, China |
| Abstract: | Sestrin2 (SESN2) is a conserved stress-inducible protein (also known as hypoxia-inducible gene 95 (HI95)) that is induced under hypoxic conditions. SESN2 represses the production of reactive oxygen species (ROS) and provides cytoprotection against various noxious stimuli, including hypoxia, oxidative stress, endoplasmic reticulum (ER) stress and DNA damage. In recent years, the determination of the regulation and signalling mechanisms of SESN2 has increased our understanding of its role in the hypoxic response. SESN2 has well-documented roles in hypoxia-related diseases, making it a potential target for diagnosis and treatment. This review discusses the regulatory mechanisms of SESN2 and highlights the significance of SESN2 as a biomarker and therapeutic target in hypoxia-related diseases, such as cancer, respiratory-related diseases, cardiovascular diseases and cerebrovascular diseases. |
| Keywords: | cytoprotection hypoxia regulatory mechanism sestrin2 therapeutic target |