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Differential value of intima thickness in ischaemic stroke due to large-artery atherosclerosis and small-vessel occlusion |
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| Authors: | Suqin Jin Cheng Zhang Yun Zhang Guoyong Jia Mei Zhang Mingjun Xu |
| Affiliation: | 1. Department of Neurology, The Second Hospital of Shandong University, Jinan, China Contribution: Formal analysis (equal), Investigation (equal), Methodology (equal), Writing - original draft (equal);2. The Key Laboratory of Cardiovascular Remodelling and Function Research, Department of Cardiology, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China;3. Department of Neurology, Qilu Hospital of Shandong University, Jinan, China Contribution: Investigation (equal), Methodology (equal);4. The Key Laboratory of Cardiovascular Remodelling and Function Research, Department of Cardiology, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China Contribution: Conceptualization (equal), Writing - review & editing (equal) |
| Abstract: | No study has examined the differential value of arterial intima thickness in the subtypes of acute ischaemic stroke. This study aimed to assess whether intima thickness of carotid artery (CIT), radial artery (RIT) and dorsalis pedis artery (PIT) have an independent and additive value in differentiating ischaemic stroke subtypes due to large-artery atherosclerosis (LAA) or small-vessel occlusion (SVO). One hundred and sixty-one patients with LAA and 79 patients with SVO were recruited. CIT, RIT and PIT were measured with a 24-MHz ultrasound transducer. Binary logistic regression analysis was used to evaluate the differential values of the different parameters in the two subtypes. ROC curve analyses were plotted to compare the differential performance of different parameters and the combination model. Both RIT and PIT were substantially thicker in LAA than in SVO stroke patients. RIT and carotid intima-media thickness had similar performances in differentiating stroke subtypes. Introduction of RIT to traditional atherosclerotic associated risk factors had a marginal satisfactory differential performance for LAA and SVO stroke patients (AUC 0.775). RIT is a promising parameter for LAA and SVO subgroup classification. The combination of RIT and traditional risk factors might be a promising tool for differentiating ischaemic stroke subgroups. |
| Keywords: | carotid artery intima thickness large-artery atherosclerosis radial artery small-vessel occlusion |