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Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction |
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| Authors: | Chunfang Wang Leiling Liu Yishu Wang Danyan Xu |
| Affiliation: | 1. Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China Contribution: Conceptualization (lead), Supervision (lead), Writing - original draft (lead), Writing - review & editing (lead);2. Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China Contribution: Writing - review & editing (supporting);3. Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China |
| Abstract: | Mitochondria are important organelles in eukaryotic cells. Normal mitochondrial homeostasis is subject to a strict mitochondrial quality control system, including the strict regulation of mitochondrial production, fission/fusion and mitophagy. The strict and accurate modulation of the mitochondrial quality control system, comprising the mitochondrial fission/fusion, mitophagy and other processes, can ameliorate the myocardial injury of myocardial ischaemia and ischaemia-reperfusion after myocardial infarction, which plays an important role in myocardial protection after myocardial infarction. Further research into the mechanism will help identify new therapeutic targets and drugs for the treatment of myocardial infarction. This article aims to summarize the recent research regarding the mitochondrial quality control system and its molecular mechanism involved in myocardial infarction, as well as the potential therapeutic targets in the future. |
| Keywords: | ischemia-reperfusion mitochondrial apoptosis mitochondrial fission mitochondrial fusion mitochondrial quality control myocardial infarction |