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Anti-inflammatory mechanisms and research progress of colchicine in atherosclerotic therapy |
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| Authors: | Yuyu Li Yuxin Zhang Jianrong Lu Yong Yin Jun Xie Biao Xu |
| Institution: | 1. Department of Cardiology, Nanjing Drum Tower Hospital, MOE Key Laboratory of Model Animal for Disease Study, School of Medicine, Nanjing University, Nanjing, China;2. Institution of Translational Medicine, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China
Contribution: Investigation (equal), Methodology (equal), Validation (equal), Writing - review & editing (equal);3. Department of Cardiology, Nanjing Drum Tower Hospital, MOE Key Laboratory of Model Animal for Disease Study, School of Medicine, Nanjing University, Nanjing, China Contribution: Data curation (supporting), Formal analysis (supporting), Visualization (supporting);4. Department of Cardiology, Nanjing Drum Tower Hospital, MOE Key Laboratory of Model Animal for Disease Study, School of Medicine, Nanjing University, Nanjing, China Contribution: Formal analysis (supporting), Supervision (supporting), Validation (supporting) |
| Abstract: | Inflammatory responses play a vital role in the onset and development of atherosclerosis, and throughout the entire process of the chronic disease. The inflammatory responses in atherosclerosis are mainly mediated by the NLRP3 inflammasome and its downstream inflammatory factors. As a powerful anti-inflammatory medicine, colchicine has a history of more than 200 years in clinical application and is the first-choice treatment for immune diseases such as gout and familial Mediterranean fever. In atherosclerosis, colchicine can inhibit the assembly and activation of NLRP3 inflammasome via various mechanisms to effectively reduce the expression of inflammatory factors, thereby reducing the inflammation. Recent clinical trials show that a low dose of colchicine (0.5 mg per day) has a certain protective effect in stable angina patients or those with acute myocardial infarction after PCI. This article summarizes and discusses the mechanisms of colchicine in the treatment of atherosclerosis and the latest research progress. |
| Keywords: | atherosclerosis colchicine NLRP3 inflammasome |