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Circular RNA in cardiovascular disease: Expression,mechanisms and clinical prospects |
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| Authors: | Ying Tang Jinghui Bao Jiahui Hu Leiling Liu Dan-Yan Xu |
| Institution: | 1. Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China
Contribution: Conceptualization (lead), Data curation (lead), Formal analysis (lead), Funding acquisition (lead), ?Investigation (lead), Methodology (lead), Project administration (lead), Resources (lead), Software (lead), Supervision (lead), Validation (lead), Visualization (lead), Writing - original draft (lead), Writing - review & editing (lead);2. Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China Contribution: Funding acquisition (supporting);3. Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China Contribution: Project administration (supporting), Visualization (supporting);4. Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China Contribution: ?Investigation (supporting), Validation (supporting);5. Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China |
| Abstract: | Circular RNAs (circRNAs) are a group of covalently closed, endogenous, non-coding RNAs, which exist widely in human tissues including the heart. Increasing evidence has shown that cardiac circRNAs play crucial regulatory roles in cardiovascular diseases (CVDs). In this review, we aimed to provide a systemic understanding of circRNAs with a special emphasis on the cardiovascular system. We have summarized the current research on the classification, biogenesis and properties of circRNAs as well as their participation in the pathogenesis of CVDs. CircRNAs are conserved, stable and have specific spatiotemporal expression; thus, they have been accepted as a potential diagnostic marker or an incremental prognostic biomarker for CVDs. |
| Keywords: | biogenesis cardiovascular disease circRNA miRNA RNA-binding protein |