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Elabela may regulate SIRT3-mediated inhibition of oxidative stress through Foxo3a deacetylation preventing diabetic-induced myocardial injury |
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| Authors: | Cheng Li Xiao Miao Shudong Wang Yucheng Liu Jian Sun Quan Liu Lu Cai Yonggang Wang |
| Institution: | 1. Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun, Jilin, China;2. The Second Hospital of Jilin University, Changchun, Jilin, China
Contribution: Data curation (equal), Formal analysis (equal);3. Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun, Jilin, China Contribution: Funding acquisition (supporting), Resources (supporting), Writing - review & editing (equal);4. Osteopathic Medicine Candidate, A.T. Still University School of Osteopathic Medicine in Arizona, Mesa, AZ, USA Contribution: Writing - review & editing (lead);5. Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun, Jilin, China Contribution: Funding acquisition (equal), Resources (equal), Supervision (equal);6. Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun, Jilin, China Contribution: Funding acquisition (equal), Supervision (equal);7. Departments of Pediatrics, Pediatric Research Institute, The University of Louisville School of Medicine, Louisville, KY, USA |
| Abstract: | Diabetic cardiomyopathy—pathophysiological heart remodelling and dysfunction that occurs in absence of coronary artery disease, hypertension and/or valvular heart disease—is a common diabetic complication. Elabela, a new peptide that acts via Apelin receptor, has similar functions as Apelin, providing beneficial effects on body fluid homeostasis, cardiovascular health and renal insufficiency, as well as potentially beneficial effects on metabolism and diabetes. In this study, Elabela treatment was found to have profound protective effects against diabetes-induced cardiac oxidative stress, inflammation, fibrosis and apoptosis; these protective effects may depend heavily upon SIRT3-mediated Foxo3a deacetylation. Our findings provide evidence that Elabela has cardioprotective effects for the first time in the diabetic model. |
| Keywords: | apoptosis diabetic cardiomyopathy elabela oxidative stress SIRT3 |