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Prognostic role of c-Jun activation domain-binding protein-1 in cancer: A systematic review and meta-analysis |
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| Authors: | Deyao Shi Shidai Mu Binwu Hu Shuo Zhang Jianxiang Liu Zhicai Zhang Zengwu Shao |
| Institution: | 1. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Contribution: Data curation (lead), Formal analysis (lead), Investigation (lead), Methodology (equal), Software (lead), Validation (equal), Writing - original draft (lead);2. Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (supporting);3. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Contribution: Data curation (supporting), Investigation (supporting);4. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Contribution: Formal analysis (supporting), Investigation (supporting);5. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Contribution: Formal analysis (supporting), Investigation (supporting), Methodology (supporting);6. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |
| Abstract: | c-Jun activation domain-binding protein-1 (Jab1) is aberrantly overexpressed in multiple cancers and plays an oncogenic role in cancer progression. We examined the association between Jab1 expression and prognosis in patients with cancer by conducting a meta-analysis. A comprehensive search strategy was performed using the PubMed, Web of Science, Ovid and EMBASE in July 2020. Eligible studies were enrolled according to definite criteria. Twenty-seven studies involving 2609 patients were enrolled in this meta-analysis. A significant association between high Jab1 expression and poor overall survival (pooled hazard ratio HR] 2.344, 95% confidence interval CI]: 2.037-2.696) was observed. Subgroup analyses of the type of cancer, sample size, follow-up period, Jab1 detection method and preoperative treatment did not alter the significance. On pooling data from Cox multivariate analyses, high Jab1 expression was found to be an independent prognostic indicator for overall survival. In addition, high Jab1 expression was found to be associated with advanced clinicopathological features such as clinical stage, lymphatic metastasis, histological grade and distant metastasis in cancers. Our meta-analysis is the first to demonstrate that high Jab1 expression may be a promising indicator of poor prognosis and has an independent prognostic value for overall survival in patients with cancer. |
| Keywords: | biomarker cancer Jab1 meta-analysis prognosis |