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A rapid, hygienic method for the preparation of fecal samples for liquid scintillation counting.
Authors:B J Morrison  R A Franklin
Institution:Drug Metabolism Section, Wyeth Laboratories, Huntercombe Lane South, Taplow, Maidenhead, Berks, England
Abstract:A method for the preparation of fecal samples for liquid scintillation counting is described which is rapid, hygienic, and inexpensive. By the use of a novel type of homogenizer, fecal samples can be homogenized while totally enclosed within a sealed, plastic bag, so reducing the possible risk of infection. The subsequent preparation of a clear solution suitable for liquid seintillation counting is performed using an “in-vial” digestion technique which enables any 14CO2 released during digestion to be trapped within the vial.
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