左旋精氨酸在冠脉搭桥术中心肌保护作用研究进展

冠状动脉搭桥术(Coronary artery bypass grafting,CABG)中发生心肌缺血再灌注损伤是难以避免的,而冠状动脉内皮损伤导致一氧化氮(nitrogen monoxidum NO)合成及释放减少是导致心肌缺血/再灌注损伤(Myocardial ischemia/reperfusion injury MI/RI)的重要因素。本文通过对左旋精氨酸(left-arginine,L-Arg)与NO、MI/RI之间的联系、L-Arg对MI/RI的保护作用及其机制、L-Arg-NO的心肌保护作用与剂量之间关系以及L-Arg在CABG中的临床应用等方面的研究进行综述,阐明提供外源性L-Arg通过L-Arg-NO通路促进体内NO的合成及释放,探讨左旋精氨酸在冠脉搭桥术中心肌保护作用的可行性。

The Development of Left-arginine On Myocardial Protection during Coronary Artery Bypass Graft

The ischemia reperfusion injury of myocardial is unavoidable in coronary artery bypass grafting and the important reason of causing myocardial ischemia reperfusion injury is coronary artery endothelial injury which could cause the reducing of nitric oxide synthesis and release. This study is aim to explore the feasibility of L-Arg about myocardial protection function in coronary artery bypass grafting, through elaborating on the relation among L-Arg,NO and MI/RI; protection function and mechanism of L-Arg to MI/RI; the relationship between Myocardial protection and L-Arg dose and the clinical application of L - Arg in coronary artery bypass grafting.