影响口腔鳞状细胞癌患者预后的临床病理因素分析

目的:研究影响口腔鳞状细胞癌(Oral squamous cellcar cinoma,OSCC)术后患者预后的临床病理因素。方法:回顾性研究55例手术治疗的原发口腔鳞状细胞癌患者与预后相关的因素:年龄、性别、发病部位、颈部淋巴结转移情况、肿瘤细胞分化程度等。结果:平均发病年龄为57.35±12.02岁,牙龈鳞癌的复发转移率最高(45.5%),舌部第二(44%),颊部第三(37.5%),唇癌预后最好(0.0%)。术前颈部淋巴结转移情况、肿瘤细胞分化程度与预后有关。肿瘤细胞的分化程度与术前淋巴结转移无显著相关性。术前有颈部淋巴结转移合并中低分化与预后差相关。结论:口腔鳞状细胞癌的预后与发病部位无显著相关性。肿瘤中低分化及术前有淋巴结转移者易出现术后复发转移。

Clinical Pathology and Prognostic Factors in Oral SquamousCell Carcinoma

Objective: The study goal was to determine which clinical features correlated with prognosis in patients surgicallytreated for oral squamous cell carcinoma (OSCC). Methods: The records of 55 OSCC patients surgically treated were reviewed retrospectively.Their prognosis in relation to age, gender, tumor site, neck lymph node involvement, differentiation were analyzed. Results: Themean age is 57.35±12.02 years. Tumor recurrence or neck nodal metastasis occurred frequently at gingiva (in 45.5 % of cases), followedby tongue (44%), buccal mucosa (37.5%), and lip (0.0%). The nodal involvement, cell differentiation significantly affected the prognosis(P <0.05, x2 test). Tumor cell differentiation was no correlated with lymph node metastasis. Combined neck nodal metastasis and poordifferentiation was associated with poor clinical outcome (P<0.05). Conclusions: We conclude that site had little influence on prognosis.Neck lymph nodal metastasis and poor differentiation are significant prognostic factor of oral squamous cell carcinoma.