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Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer |
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| Authors: | Ross R. Keller Edward J. Gunther |
| Affiliation: | 1. Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA;2. Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA;3. Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA |
| Abstract: |  |
| Keywords: | clonal evolution oncogene overdose mouse Wnt signaling mammary cancer breast cancer Apc gene cancer genetics targeted therapy drug resistance |
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