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Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution
Authors:Tobias Messmer  Ferdinand von Meyenn  Aurora Savino  Fátima Santos  Hisham Mohammed  Aaron Tin Long Lun  John C. Marioni  Wolf Reik
Affiliation:1. Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK;2. Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany;3. Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK;4. Department of Medical and Molecular Genetics, King’s College London, London SE1 9RT, UK;5. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK;6. EMBL European Bioinformatics Institute, Wellcome Genome Campus, Hinxton CB10 1SD, UK
Abstract:
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  • Keywords:human embryonic stem cells  pluripotency  single-cell RNA-seq  naive  primed  heterogeneity  early embryonic development  evolution
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