Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. |
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| Authors: | R G Knowles M Merrett M Salter S Moncada |
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| Affiliation: | Wellcome Research Laboratories, Beckenham, Kent, U.K. |
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| Abstract: | Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation. |
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