Localization and ordering of acid alpha-glucosidase (GAA) and thymidine kinase (TK1) by fluorescence in situ hybridization |
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| Authors: | Wen-Lin Kuo Rochelle Hirschhorn Maryann L Huie Kurt Hirschhorn |
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| Institution: | (1) Division of Molecular Cytometry, Department of Laboratory Medicine, University of California, 94143 San Francisco, CA, USA;(2) Division of Medical Genetics, Department of Medicine, New York University School of Medicine, 10016 New York, NY, USA;(3) Departments of Pediatrics and Human Genetics, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1497, 10029-6474 New York, NY, USA |
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| Abstract: | Genomic DNA clones of human acid alpha glucosidase (GAA) and thymidine kinase (TK1) were used to map the exact location and order of these genes on human chromosome 17. Both genes were localized to the 17825-gter band (17825.2–825.3), with GAA distal to TK1. They were also shown to be, respectively, distal and proximal to an anonymous cosmid (cK17.71) previously mapped to this region. |
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