杆状病毒p35蛋白抗凋亡作用及机理

杆状病毒入侵可以诱导昆虫细胞凋亡,作为对抗宿主防御体系的一种策略,病毒自身编码具有抗细胞凋亡活性的蛋白,如p35蛋白和IAP。杆状病毒p35蛋白是一种广泛有效的凋亡抑制因子,能在哺乳纲、昆虫纲和线虫纲中抑制细胞凋亡作用,推测其与细胞凋亡途径上保守的成分Caspase起作用。研究表明,p35蛋白正是通过蛋白酶间的相互作用和p35蛋白的剪切而起作用的。就最近几年在p35蛋白抗凋亡作用机理方面的研究作一综述 。

The Antiapoptosis Activity and Molecular Mechanism of Baculovirus Protein p35

Baculovirus invasion can induce insect cell apoptosis.As a strategy of countering the apparent antiviral defense by the host,virus encodes diverse protein with antiapoptotic activity,such as IAP and protein p35.The baculovirus protein p35 is a general and effective suppressor.It is estimated that p35 targets a highly conserved step in the death pathway.Collectlly ,p35 blocks virus-induced apoptosis by inhibiting a virus-activated CED-3/ICE-like protease through a mechanism that includes protease interaction and p35 cleavage.;