Selenium status indices,laboratory data,and selected biochemical parameters in end-stage renal disease patients |
| |
Authors: | Paweł Zagrodzki Henryk Bartoń Stanisław Walas Maria Fołta Tomasz Stompór Eve Janusz-Grzybowska Maciej Drożdż Władysław Sułowicz |
| |
Institution: | (1) Department of Food Chemistry and Nutrition, Jagiellonian University, Krakow, Poland;(2) Department of Nephrology, Medical College, Jagiellonian University, Krakow, Poland;(3) Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Krakow, Poland;(4) H. Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland |
| |
Abstract: | We investigated the relations between selenium status (SeS) parameters, indexes of nutrition, erythropoiesis, and uremic toxemia,
serum electrolytes, and other biochemical markers in end-stage renal disease (ESRD) patients, as no multivariate statistical
analysis concerning all of these parameters was performed so far. SeS was evaluated by plasma Se concentration (plSe) and
glutathione peroxidase (plGSHPx) activity in 69 uremic patients treated with hemodialysis (HD) and 40 healthy controls. The
hierarchical multivariate partial least squares model (PLS2) was employed to establish data structure and correlations between
parameters investigated. plSe and plGSHPx activity were significantly lower in patients when compared with controls (p=0.000). plSe was positively associated with indexes of erythropoiesis and nutritional status, as well as serum electrolytes
and parameters of uremic toxemia. plGSHPx was inversely dependent on the pair of parameters: intact parathyroid hormone (iPTH)
and aluminum plasma concentration (Al). We conclude that (1) ESRD strongly decreases selenium status and (2) the PLS2 approach
revealed the existence of significant interactions among plSe, plGSHPx, and selected biochemical parameters or groups of such
parameters; some of these associations need further studies to be clarified. |
| |
Keywords: | Selenium glutathione peroxidase ESRD hemodialysis toxemia partial least squares model |
本文献已被 PubMed SpringerLink 等数据库收录! |
|